Topotecan ready to use solutions

Details Topotecan ready to use solutions Topotecan ready to use solutions

A - Human Necessities

61

K

A61K 31/4745 (2006.01)

Patent

CA 2715832

Aqueous-based, ready to use topotecan-containing formulations for parenteral use having extended stability are disclosed. The formulations are surprisingly free of precipitated degradation products such as 10-hydroxycamptothecin (10-HCPT) after periods of up to 1 year or greater.

L'invention porte sur des formulations contenant du topotécan, prêtes à l'emploi, à base aqueuse, pour une utilisation parentérale, ayant une stabilité prolongée. Les formulations sont, de façon surprenante, exemptes de produits de dégradation ayant précipité, tels que la 10-hydroxycamptothécine (10-HCPT) après des périodes de temps allant jusqu'à 1 an ou plus.

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