Torque teno virus (ttv) isolates and compositions

Details Torque teno virus (ttv) isolates and compositions Torque teno virus (ttv) isolates and compositions

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2739469

The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus ("TTV"), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.

La présente invention concerne des séquences inédites de nucléotides et d'acides aminés du torque teno virus ( » TTV »), y compris de génotypes inédits de celui-ci, que l'on peut utiliser dans le cadre de la préparation de vaccins permettant de traiter et de prévenir des maladies chez le porc et d'autres animaux. Les vaccins selon l'invention se révèlent efficaces contre de multiples génotypes et isolats du TTV de porc. L'invention concerne également des anticorps polyclonaux et monoclonaux diagnostiques et thérapeutiques, ainsi que des clones infectieux pouvant être utilisés pour la multiplication du virus et la préparation de vaccins. Des aspects particulièrement importants de l'invention concernent des vaccins utilisant, en tant qu'antigène, la protéine ORF1 du TTV ou des fragments peptidiques de celle-ci.

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