C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/64 (2006.01) A61P 7/10 (2006.01)
Patent
CA 2379322
The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol adduct. Methods for their preparation are also disclosed. The present invention also relates to processes for making torsemide modification (I). Pharmaceutical compositions containing the new forms of torsemide and methods of using them are also disclosed.
L'invention concerne de nouvelles formes de torsémide appelé Forme V, un torsémide amorphe, un adjuvant de solvant Dupont Forme 2, un adjuvant d'éthanol Dupont Forme 2, et un adjuvant d'isopropanol Dupont Forme 2, ainsi que leur préparation. L'invention concerne également des techniques permettant d'effectuer une modification (I) du torsémide. L'invention concerne, en outre, des compositions pharmaceutiques contenant les nouvelles formes de torsémide et leurs procédés d'utilisation.
Aronhime Judith
Dolitzky Ben-Zion
Kordova Marko
Leonov David
Schwartz Anchel
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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