C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2309343
The present invention is directed to novel polypeptides such a the Toso protein and related molecules which have an inhibitory effect on TNF and Fas mediated apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention concerne de nouveaux polypeptides, tels que la protéine Toso et des molécules apparentées exerçant un effet d'inhibition sur l'apoptose provoquée par l'intermédiaire de TNF, ainsi que des molécules d'acides nucléiques codant ces polypeptides. Elle concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acides nucléiques, des molécules de polypeptides chimères comprenant ces polypeptides fusionnés à des séquences de polypeptides hétérologues, des anticorps se liant à ces polypeptides et des procédés servant à obtenir ces polypeptides.
Hitoshi Yasumichi
Nolan Garry P.
Riches Mckenzie & Herbert Llp
The Board Of Trustees Of Leland Stanford Junior University
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