Total glycosides of dangshen and their use as an aid for...

A - Human Necessities – 61 – P

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A61P 25/28 (2006.01) A61K 35/78 (2000.01)

Patent

CA 2427079

Disclosed is a pharmaceutical composition comprising isolated total glycosides of dangshen. The isolated total glycosides of dangshen, extracted from dangshen herbs, are useful in a method for enhancing memory acquisition, retention and/or retrieval in a human subject and are useful for enhancing or protecting against memory impairment caused by age or by the memory-impairing effects of ethanol or other drugs or medications. Also disclosed is an extract of dangshen prepared by steps including extracting dangshen with water to produce an aqueous filtrate of an extract of dangshen containing total glycosides of dangshen; adding the aqueous filtrate to a column filled with a macro-reticular resin which selectively binds the total glycosides of dangshen; freeing the total glycosides of dangshen from the macro-reticular resin by eluting the total glycosides of dangshen from the column with an alcohol; and separating the total glycosides of dangshen from the alcohol.

L'invention concerne une composition pharmaceutique comprenant des glycosides totaux isolés de dangshen. Les glycosides totaux isolés de dangshen, extraits d'herbes de dangshen, sont utilisés dans une méthode destinée à améliorer la mémorisation, la fixation mnémonique et/ou la remémoration chez un être humain et sont utilisés pour protéger contre les pertes de mémoire induites par l'âge ou par les effets néfastes de l'éthanol ou d'autres produits thérapeutiques ou de médicaments sur la mémoire. L'invention concerne également un extrait de dangshen préparé selon un procédé consistant à extraire le dangshen avec de l'eau pour produire un filtrat aqueux d'un extrait de dangshen contenant des glycosides totaux de dangshen, à ajouter le filtrat aqueux dans une colonne remplie avec une résine macroréticulaire qui fixe sélectivement les glycosides totaux de dangshen, à libérer les glycosides totaux de dangshen de la résine macroréticulaire par élution des glycosides totaux de dangshen de la colonne par de l'alcool, et à séparer les glycosides totaux de dangshen de l'alcool.

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