C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2107463
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoie-tic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in Figure 1 (flk-2) and Figure 2(flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in Figure 1 (flk-2) and Figure 2 (flk-1); ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the prolif-eration and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a li-gand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
Gowling Lafleur Henderson Llp
The Trustees Of Princeton University
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