Toxic agent protective compounds, compositions and method

Details Toxic agent protective compounds, compositions and method Toxic agent protective compounds, compositions and method

C - Chemistry, Metallurgy

07

C

C07C 323/58 (2006.01) A61K 9/127 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01)

Patent

CA 2089158

2089158 9204024 PCTABS00011 Novel and known compounds are identified which possess protective properties against the toxic effects of electrophilic agents upon human and/or animal bodies, and the use of these compounds for the production of compositions for the protection of such bodies against those electrophiles is particularly provided. The compounds and compositions are effective against topically or systemically administered agents which are themselves electrophiles or which are metabolised to produce electrophilic products in the body. A particularly advantageous aspect of the present invention lies in the application of these compounds and compositions as protectants against inhaled electrophiles and their precursors. Some radioprotectant activity against intracellularly produced electrophiles will be provided due to the ability of the compounds to raise intracellular cysteine levels.

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