Toxicity typing using embryoid bodies

Details Toxicity typing using embryoid bodies Toxicity typing using embryoid bodies

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01F 17/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2353309

This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian embryoid bodies contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions.

Cette invention concerne des procédés et des systèmes permettant l'identification et le typage de la toxicité de compositions chimiques, de même que l'analyse de nouvelles compositions visant à déceler leur toxicité. L'invention concerne aussi la détection de modifications dans l'expression des gènes ou de protéines, permettant ainsi d'établir des profils moléculaires dans des corps embryoïdes mammaliens isolés mis en contact avec diverses compositions chimiques dont les toxicités sont connues ou inconnues, et de mettre en corrélation ces profils moléculaires avec les toxicités des compositions chimiques.

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