Toxicity typing using liver stem cells

Details Toxicity typing using liver stem cells Toxicity typing using liver stem cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2412361

This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions.

L'invention concerne des procédés et des systèmes permettant d'identifier et de typer la toxicité de compositions chimiques ainsi que de cribler les nouvelles compositions pour rechercher leur toxicité. L'invention concerne également la détection d'altérations dans un gène ou dans l'expression d'une protéine et permet ainsi d'établir des profils moléculaires dans des cellules embryonnaires de foie de mammifères isolés mises en contact avec diverses compositions chimiques de toxicités connues ou inconnues et mettant en corrélation les profils moléculaires avec les toxicités des compositions chimiques.

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