Toxicity typing using mesenchymal stem cells

Details Toxicity typing using mesenchymal stem cells Toxicity typing using mesenchymal stem cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2412769

This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian MSCs contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions.

La présente invention concerne des procédés et des systèmes permettant non seulement d'identifier et de typer la toxicité de compositions chimiques, mais aussi d'analyser de nouvelles compositions dans le but de déceler leur toxicité. Les procédés selon l'invention consistent à détecter des modifications au niveau de l'expression de gènes ou de protéines, ce qui permet d'établir des profils moléculaires dans des cellules souches mésenchymateuses mammaliennes isolées mises en contact avec diverses compositions chimiques à toxicité connue ou inconnue, et de mettre en corrélation ces profils moléculaires avec la toxicité des compositions chimiques.

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