Toxin conjugates

Details Toxin conjugates Toxin conjugates

C - Chemistry, Metallurgy

07

K

167/129, 530/17.

C07K 7/08 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C07K 14/415 (2006.01) C07K 16/30 (2006.01) C07K 17/06 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12N 15/69 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1271900

TOXIN CONJUGATES Abstract A novel class of polypeptides of the general formula (F-(Pro)n)mF, wherein F represents a flexible amino acid sequence wherein each amino acid is individually selected from the group consisting of serine, glycine, and threonine, and n is an integer from 4-8 inclusive and m is an integer from 1-4 inclusive, is disclosed. These polypeptides are useful in the construction of conjugates between antibodies and peptide toxins. The preparation of such conjugate toxins by linking antibodies to toxin/spacer composites prepared by recombinant techniques is also disclosed.

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