Toxin peptide therapeutic agents

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) C07K 14/435 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2667678

Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

L'invention concerne une composition de matière comprenant un analogue peptidique d'OSK1, et dans certains modes de réalisation, un sel pharmaceutiquement acceptable de ce dernier. Une composition pharmaceutique comprend ladite composition et un support pharmaceutiquement acceptable. L'invention concerne également des ADN codant pour la composition de matière de l'invention, un vecteur d'expression comprenant l'ADN, ainsi que des cellules hôtes comprenant le vecteur d'expression. L'invention concerne enfin des méthodes de traitement d'un trouble auto-immun et de prévention ou d'atténuation d'une récidive d'un symptôme de sclérose en plaques.

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