C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) C07K 14/39 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2484704
Anti-idiotypic antibodies which recognise the idiotope of an antibody specific for a yeast killer toxin possess microbicidal activity. Fragments (e.g. decapeptides) of these anti-idiotypic antibodies, particularly those comprising CDR residues, also show microbicidal activity, as do peptides having 5 the same sequence but composed of D-amino acids, or including amino acid substitutions. Peptidomimetics of these microbicidal polypeptides are also provided. Antiviral activity is also seen.
L'invention concerne des anticorps anti-idiotypiques reconnaissant l'idiotope d'un anticorps propre à une toxine "killer" produite par la levure, lesquels ont une activité microbicide. Des fragments (par exemple, des décapeptides) de ces anticorps anti-idiotypiques, plus particulièrement, ceux qui comprennent des restes de CDR, ont également une activité microbicide; il en va de même pour les peptides qui présentent la même séquence mais qui sont constitués d'acides aminés D, ou qui contiennent des substitutions d'acides aminés. L'invention concerne également des peptidomimétiques de ces polypeptides microbicides, ainsi que leur activité antivirale.
Bracci Luisa
Cassone Antonio
Lozzi Luisa
Neri Paolo
Polonelli Luciano
Cassone Antonio
Dennison Associates
Polonelli Luciano
Universita Degli Studi Di Siena
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