A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/135
A61K 39/02 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 9/52 (2006.01) C12N 9/66 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1085293
ABSTRACT OF THE DISCLOSURE Novel toxoids derived from protease and elastase of Pseudomonas aeruginosa having the following physicochemical properties: (a) the toxoid derived from the protease: (1) Molecular weight: 63000 (gel filtration) (2) Ultraviolet absorption spectrum: maximum 280 mµ Image , Minimum 250 mµ (3) Isoelectric point:. pH 5.2 (forcal electrophoresis) (4) Constituent amino acids: (amino acid (g)/100 g of protein), aspartic acid (15.6), glutamic acid (9.5), leucine (8.7), alanine (8.5), glycine (7.7), serine (7.6), tyrosine (6.9), phenylalanine (5.9), threonine (5.0), valine (5.0), lysine (4.1), isoleucine (3.9), arginine (2.3), tryptophan (2.3), proline (2.1), histidine (1.0), ammonia (1.4) (total 98.5 g) (5) Appearance: colorless powder (6) Antigen activity: positive (7) Protease activity: negative. (b) the toxoid derived fxom the elastase: (1) Molecular weight: 47000(gel filtration) (2) Ultraviolet absorption spectrum: maximum 278 mµ Image , minimum 252 mµ (3) Isoelectric point: pH 6.5 (electrophoresis with cellulose acetate membrane) (4) Constituent amino acids: (amino acid (g)/100 of protein), aspartic acid (14.2), tyrosine (9.9), phenyl- alanine (7.0), glutamic acid (6.5), arginine (6.5), alanine (5.8), glycine (5.6), serine (5.6), threonine (5.0), valine (4.9), leucine (4.3), lysine (3.9), methionine (2.9), proline (2.9), isoleucine (2.7), histidine (2.6), tryptophan (2.3), cystine/2 (1.2), ammonia (0.9), (total 94.7 g) (5) Appearance: colorless powder (6) Antigen activity: positive (7) Elastase activity: negative where found to be effective to prevent and treat infections caused by Pseudomonas aeruginosa. A process for their preparation includes inactivating the protease or elastase in a buffer solution with formalin or oxymethanesulfinic acid.
270134
Homma Yuzuru
Morihara Kazuyuki
Johnson Douglas S. Q.c.
Shionogi & Co. Ltd.
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