Toxoids of elastase of pseudomonas aeruginosa origin

C - Chemistry – Metallurgy – 12 – N

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C12N 9/66 (2006.01) A61K 39/04 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1256370

ABSTRACT OF DISCLOSURE Provided herein are two kinds of toxoid of elastase of Pseudomonas aeruginosa origin, one of which is obtained by treating a purified elastase produced from Pseudomonas aeruginosa with a synthetic peptide for chloroacetyl-N-hydroxy-L-leucyl-L-alanylglycinamide and the other of which is obtained by treating at first with formalin, then, with the synthetic peptide. The present invention also contemplates a method for preparing the toxoids and the use of such toxoids for preventing and treating infections caused by Pseudomonas aeruginosa on human beings and mammalian animals. Acute toxicity of the toxoids is inspected. ?

472532

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