Tpl-2/cot kinase and methods of use

Details Tpl-2/cot kinase and methods of use Tpl-2/cot kinase and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/00 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) A61K 31/4706 (2006.01) A61K 31/4745 (2006.01) A61K 38/45 (2006.01) A61P 1/00 (2006.01) A61P 5/48 (2006.01) C07K 14/82 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339036

It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NF~B, and thus as a modulator of inflammatory responses in which p105 is involved, and as a target for the development of compounds capable of influencing NF~B activation.

La présente invention démontre que TPL-2 est responsable de la phosphorylation de p105 et de la protéolyse qui en résulte, provoquant la translocation p50 REL du noyau. De même, cette invention concerne TPL-2 comme régulateur spécifique de l'activation de NF~B, et par conséquent comme modulateur des réactions inflammatoires dans lesquelles p105 est impliqué, et comme cible pour l'élaboration de composés capables d'influencer l'activation de NF~B.

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