Trail receptor 2 polypeptides and antibodies

Details Trail receptor 2 polypeptides and antibodies Trail receptor 2 polypeptides and antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2620470

Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ("TRAIL") Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

L'invention concerne des polypeptides et des domaines de liaison aux anticorps ou aux antigènes se liant à de tels polypeptides. L'invention concerne également des procédés permettant d'obtenir un anticorps se liant au récepteur-2 (TR-2) de ligand inducteur de l'apoptose liée au facteur de nécrose des tumeurs (TNF) ("TRAIL") et consistant à administrer au moins un de ces polypeptides à un animal et à obtenir un anticorps se liant à TR-2 de l'animal. L'invention concerne également des anticorps réactifs avec TR-2 et des cellules produisant des anticorps réactifs avec TR-2, des compositions pharmaceutiques comprenant des anticorps réactifs avec TR-2, des procédés d'utilisation des anticorps réactifs avec TR-2 et des kits comprenant des anticorps réactifs avec TR-2. L'invention concerne, en outre, des procédés permettant de diminuer ou de prévenir la liaison d'un anticorps à TR-2 et consistant à administrer un tel polypeptide.

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