Trail receptor-binding agents and uses of the same

Details Trail receptor-binding agents and uses of the same Trail receptor-binding agents and uses of the same

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2649872

This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.

L'invention porte, de manière générale, sur la préparation d'agents de liaison du récepteur TRAIL et leurs utilisations, et plus particulièrement, sur la préparation d'anticorps dirigés contre le récepteur TRAIL, qui reconnaissent un déterminant antigène commun (par exemple épitope) associé aux récepteurs TRAIL-R1 et TRAIL-R2, et sur leur utilisation pour la détection et la modulation de la fonction induite par le récepteur TRAIL. Ces agents sont utilisés pour induire l'apoptose chez les cellules cancérigènes humaines. Ces cibles expriment TRAIL-R1 et/ou TRAIL-R2. L'invention porte aussi sur l'utilisation des agents de liaison du récepteur TRAIL dans les traitements contre le cancer.

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