Tramadol, salts thereof and process for their preparation

Details Tramadol, salts thereof and process for their preparation Tramadol, salts thereof and process for their preparation

C - Chemistry, Metallurgy

07

C

C07C 213/00 (2006.01) C07C 213/10 (2006.01) C07C 217/74 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2295884

Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydrochloride. Also claimed is the base hydrate of cis-Tramadol per se and its use as a medicament.

Pour élaborer ce cis-Tramadol à l'état hydrochlorure, on commence par former un hydrochlorure de Mannich, puis on provoque la libération de la base de Mannich, on fait réagir cette base de Mannich avec un réactif de Grignard de façon à former un hydrate base de cis-Tramadol servant à former un cis-Tramadol à l'état hydrochlorure pur. L'invention concerne également un hydrate base de cis-Tramadol en tant que tel et son utilisation comme médicament.

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