(+)-trans-3-¬(4-methoxyphenoxy)-methyl|-1-...

Details (+)-trans-3-¬(4-methoxyphenoxy)-methyl|-1-... (+)-trans-3-¬(4-methoxyphenoxy)-methyl|-1-...

C - Chemistry, Metallurgy

07

D

260/292.3

C07D 211/22 (2006.01)

Patent

CA 1265522

ABSTR~CT OF THE DISCLOSURE A process for the optical resolution of the enantio- mers of trans-3-[(4-methoxyphenoxy)-methyl]-1-methyl-4-phenyl- piperidine, which involves reaction with an enantiomer of mandelic acid to form a mixture of diastereomeric compounds, precipitating one of the diastereoisomers, and converting it to the desirable free (+)-trans isomer, as well as the key diastereomeric isomer intermediate, is disclosed.

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