C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/427 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2505368
The present invention provides new trans-9,10-dehydroepothilone C and trans- 9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.
L'invention concerne de nouveaux composés dérivés à base de trans-9,10-déhydroépothilone C et trans-9,10-déhydroépothilone D, des compositions et des procédés d'inhibition de l'hyperprolifération cellulaire et/ou de stabilisation de microtubules in vitro et de traitement de maladies hyperproliférantes in vivo. L'invention concerne également des procédés de production de ces composés.
Li Yong
Myles David
Sundermann Kurt
Tang Li
Gowling Lafleur Henderson Llp
Kosan Biosciences Incorporated
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