(+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)...

Details (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)... (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)...

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01) C07F 9/40 (2006.01) C07F 9/6509 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2499889

The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.

La présente invention concerne des trans-isomères (+) de dérivés de nucléoside ( 1-phosphonométhoxy-2-alkylcyclopropyl)méthyle représentés par la formule (1) qui conviennent comme agent antiviraux (en particulier dirigés contre le virus de l'hépatite B), des sels, des hydrates ou des solvates de ceux-ci répondant aux normes pharmaceutiques, des processus de préparation de stéréo-isomères des composés représentés par la formule (1) et, une composition destinée au traitement de maladies virales (dirigée en particulier contre l'hépatite B) qui comprend des trans-isomères (+) du composé représenté par la formule (1), un sel, un hydrate ou un solvate de celui-ci utilisés comme principe actif.

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