Trans-splicing ribozymes

Details Trans-splicing ribozymes Trans-splicing ribozymes

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01H 5/00 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C07K 14/34 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/66 (2006.01) C12N 15/82 (2006.01) C12N 15/87 (2006.01) C12N 15/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2100068

2100068 9213090 PCTABS00014 The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. Inactive pro-ribozyme forms are also described.

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