A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2648718
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake. In addition, the present invention provides compositions and methods for the detection, treatment, and prevention of diseases associated with deregulated cell growth, including, e.g., cancer and autoimmune disorders, including compositions and methods that inhibit cobalamin uptake.
L'invention concerne des séquences d'acides aminés et des séquences polynucléotidiques du récepteur de la transcobalamine, ainsi que des modulateurs du récepteur de la transcobalamine. L'invention concerne également des compositions et des procédés destinés à traiter et à prévenir des maladies et des troubles associés à une déficience en cobalamine, notamment des compositions et des procédés favorisant le captage de la cobalamine. En outre, l'invention concerne des compositions et des procédés permettant de détecter, de traiter et de prévenir des maladies associées à une croissance cellulaire dérégulée, notamment des troubles cancéreux et des troubles auto-immuns par exemple, comprenant des compositions et des procédés qui inhibent le captage de la cobalamine.
Quadros Edward V.
Sequeira Jeffrey M.
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
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