C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2433492
A complex composed of a transcriptional co-activator selected from among ARNT1 to 3 and a transcriptional regulatory factor having one of the amino acid sequences represented by SEQ ID NOS:1 to 3 etc., characterized by being capable of binding to a DNA region (5'-ACGTG-3', SEQ ID NO:16), to which a transcriptional repressing complex composed of the above-described transcriptional co-activator and a transcriptional regulatory factor Sim2 can bond, and being capable of promoting the transcription of a gene located in the downstream of the DNA region as described above, and the like are provided.
Un complexe composé d'un co-activateur transcriptionnel sélectionné parmi RNAT 1 à 3 et un facteur régulateur transcriptionnel possédant une des séquences d'acides aminés représentées par les SEQ ID NOS:1 à 3, etc., caractérisées en ce qu'elles sont capables de se lier à la région d'ADN (5'-ACGTG-3', SEQ ID NO:16), à laquelle peuvent se lier un complexe de répression transcriptionnel composé du co-activateur transcriptionnel décrit ci-dessus et un facteur de régulation transcriptionnel Sim2; il est capable de promouvoir la transcription d'un gène situé en aval de la région d'ADN, décrite plus haut.
Marks & Clerk
Sumitomo Chemical Company Limited
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