C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2634291
A double-stranded decoy oligodeoxynucleotide, the decoy oligodeoxynucleotide comprising a first strand of deoxynucleotides and a second strand of deoxynucleotides substantially complementary to the first strand of deoxynucleotides, the decoy oligodeoxynucleotide comprising at least two cis elements, each of the cis elements specifically targeting a transcription factor. Also, methods of using the decoy oligodeoxynucleotide.
L'invention concerne un oligodésoxynucléotide bicaténaire servant de leurre, comprenant un premier brin de désoxynucléotides, et un second brin de désoxynucléotides sensiblement complémentaire au premier brin de désoxynucléotide. Cet oligodésoxynucléotide formant leurre comprend au moins deux éléments cis. Chaque élément cis cible spécifiquement un facteur de transcription. L'invention concerne également des méthodes d'utilisation de cet oligodésoxynucléotide formant leurre.
Institut de Cardiologie de Montreal
Tessier Louis
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