Transcription factor modulating compounds and methods of use...

Details Transcription factor modulating compounds and methods of use... Transcription factor modulating compounds and methods of use...

C - Chemistry, Metallurgy

07

D

C07D 235/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/553 (2006.01) A61L 2/16 (2006.01) A61L 12/14 (2006.01) A61P 31/04 (2006.01) C07D 273/01 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2504448

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

La présente invention se rapporte à des composés de benzoimidazole substitués qui sont utiles en tant qu'anti-infectieux réduisant la résistance, la virulence ou la croissance des microbes. Sont également présentées des méthodes de préparation et d'utilisation de composés de benzoimidazole substitués ainsi que des préparations pharmaceutiques de ces derniers utilisées par exemple pour réduire la résistance aux antibiotiques et pour inhiber la formation de films biologiques.

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