Transcription infidelity, detection and uses thereof

Details Transcription infidelity, detection and uses thereof Transcription infidelity, detection and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01) C07K 17/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2658305

The present invention relates to the identification of a novel mechanism of transcription infidelity in cells. The invention provides compositions and methods to detect the level of transcript ion infidelity in a sample, as well as the use thereof, e.g., for therapeutic, diagnostic, pharmacogenomic or drug design. As will be disclosed, the invention is particularly suited for detecting, monitoring or treating proliferative cell disorders, for the design and/or screening of drugs, for patient or disease profiling, prediction of disease severity and evaluation of drug efficacy.

La présente invention porte sur l'identification d'un nouveau mécanisme d'infidélité de transcription dans des cellules. L'invention propose des compositions et des procédés pour détecter le niveau d'infidélité de transcription dans un échantillon, ainsi que l'utilisation de celui-ci, par exemple, pour une conception thérapeutique, de diagnostic, pharmaco-génomique ou de médicament. Comme cela sera décrit, l'invention est particulièrement appropriée pour la détection, la surveillance ou le traitement de troubles liés aux cellules proliférantes, pour la mise au point et/ou le criblage d'un médicament, pour le profilage de patients ou de maladies, la prédiction de la gravité d'une maladie et l'évaluation de l'efficacité d'un médicament.

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