Transcriptional activation inhibitory protein

Details Transcriptional activation inhibitory protein Transcriptional activation inhibitory protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370292

A protein binding to .beta.-catenin and thus inhibiting the transcriptional activation induced by the formation of a complex of .beta.-catenin with a protein belonging to the TCF/Lef family; a DNA encoding this protein; an antibody recognizing this protein; remedies containing the above protein or DNA; and diagnostics containing the above antibody.

L'invention concerne une protéine se liant à la .beta.-caténine, et inhibant l'activation transcriptionnelle induite par la formation d'un complexe de .beta.-caténine et d'une protéine appartenant à la famille TCF/Lef. Elle concerne également un ADN codant pour cette protéine, un anticorps reconnaissant ladite protéine, des médicaments contenant la protéine ou l'ADN précités, et des diagnostics contenant l'anticorps précité.

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