C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/465 (2006.01) C07K 14/47 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2436876
This invention relates to methods of modulating the development of blood vessels and/or endothelial cell differentiation in a mammal comprising altering the activity of an Ets transcription factor which activates vascular specific genes. More particularly, the transcription factor comprises ELF-1, and transcription factors that are homologous to ELF-1. The invention further relates to methods of screening for compounds that affect the development of blood vessels and/or endothelial cell differentiation. The invention also relates to methods of using these compounds to treat diseases, or symptoms of diseases, by either increasing or decreasing blood vessel development and/or endothelial cell differentiation.
L'invention se rapport à des procédés permettant de moduler la formation des vaisseaux sanguins et/ou la différentiation endothéliale chez un mammifère et consistant à modifier l'activité d'un facteur de transcription Ets qui active des gènes spécifiques des vaisseaux sanguins. Cette modulation concerne plus particulièrement le facteur de transcription ELF-1 et les facteurs de transcriptions homologues de ELF-1. L'invention concerne en outre des procédés permettant l'identification de composés qui influencent l'activité de ces facteurs de transcription et influencent de ce fait la formation des vaisseaux sanguins et/ou la différenciation des cellules endothéliales. L'invention concerne également de méthodes comprenant l'utilisation de ces composés pour le traitement de pathologies ou de symptômes de pathologies, soit par l'activation, soit par l'inhibition de la formation de vaisseaux sanguins et/ou de la différentiation des cellules endothéliales.
Libermann Towia
Oettgen Peter
Beth Israel Deaconess Medical Center
Dimock Stratton Llp
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