Transdermal administration of huperzine

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/439 (2006.01) A61K 9/70 (2006.01) A61K 31/44 (2006.01) A61K 31/4748 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01) C07D 221/06 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2389865

The present invention provides a composition of transdermally administered huperzine for improving memory and cognitive function. In one aspect, huperzine is delivered in a sufficient amount to achieve and maintain a blood plasma Huperzine level of about 0.5 ng/mL to about to 30 ng/mL. Huperzine may be delivered by itself, or in combination with other positive health promoting substances, such as vitamins, minerals, other cholinesterase inhibitors, etc. Various formulations for the transdermal delivery of huperzine are disclosed, and may include selected penetration enhancers.

La présente invention se rapporte à une composition d'huperzine destinée à une administration transdermique et visant à améliorer la mémoire et les fonctions cognitives. Selon une réalisation de l'invention, l'huperzine est administrée en quantité suffisante pour permettre d'obtenir et de conserver un taux d'huperzine dans le plasma sanguin compris entre 0,5 ng/mL environ et 30ng/mL. L'huperzine peut être administrée seule ou en association à d'autres substances favorables à la santé telles que des vitamines, des minéraux, d'autres inhibiteurs de cholinestérase, etc. L'invention se rapporte à diverses formulations destinées à l'administration transdermique d'huperzine et susceptibles de contenir des agents favorisant la pénétration.

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