Transdermal administration of phenylpropanolamine

Details Transdermal administration of phenylpropanolamine Transdermal administration of phenylpropanolamine

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/137 (2006.01) A61K 31/315 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2395289

Methods and systems are provided for the transdermal administration of racemic phenylpropanolamine, i.e., a mixture of two or more of the four isomers of phenylpropanolamine, (+)-norephedrine, (-)-norephedrine, (+)- norpseudoephedrine, and (-)-norpseudoephedrine. Generally, the racemate will be a mixture of (+)-norephedrine and (-)-norephedrine. The racemic drug is administered along with a permeation enhancer. The permeation enhancer is preferably a basic compound, and optimally is a hydroxide-releasing agent such as sodium hydroxide.

L'invention concerne des procédés et des systèmes d'administration transdermique de phénylpropanolamine racémique, c'est-à-dire un mélange d'au moins deux des quatre isomères de phénylpropanolamine, (+)-noréphédrine, (-)-noréphédrine, (+)-norpseudoéphédrine et (-)-norpseudoéphédrine. D'une manière générale, le racémate sera un mélange de (+)-noréphédrine et (-)-noréphédrine. Le médicament racémique est administré avec un agent favorisant la perméation, lequel agent est, de préférence, un composé basique, et, d'une manière optimale, un agent libérant de l'hydroxyde, par exemple l'hydroxyde de sodium.

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