Transdermal administration of ropinirole and analogs thereof

Details Transdermal administration of ropinirole and analogs thereof Transdermal administration of ropinirole and analogs thereof

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 9/70 (2006.01) A61K 31/4015 (2006.01)

Patent

CA 2233334

Transdermal administration of certain indolone derivatives which are dopamine D2 agonists is described. The method involves treating an individual afflicted with Parkinson's disease by administering an indolone derivative, e.g., ropinirole base or a pharmaceutically acceptable ropinirole salt, through the skin or mucosal tissue, for a time period and at an administration rate effective to alleviate the symptoms of the disease. Pharmaceutical formulations and drug delivery systems for administering the drugs are provided as well.

Administration transdermique de certains dérivés d'indolone qui sont des agonistes de la dopamine D¿2?. La méthode consiste à traiter un patient atteint de la maladie de Parkinson par administration d'un dérivé d'indolone, par exemple une base de ropinirole ou un sel pharmaceutiquement acceptable de ropinirole à travers la peau ou les muqueuses pendant un laps de temps et à un rythme suffisant pour soulager les symptômes de la maladie. L'invention porte également sur des formulations pharmaceutiques et des systèmes d'administration de médicament permettant d'administrer ces substances.

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