Transdermal administration of short or intermediate...

Details Transdermal administration of short or intermediate... Transdermal administration of short or intermediate...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/55 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2115841

2115841 9303694 PCTABS00020 Method and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolamine or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The composite (10) comprises an impermeable backing layer (11) and a reservoir layer (12) containing the benzodiazepine and a permeation enhancer combined with a solvent-based acrylic polymer adhesive with the amounts of benzodiazepine and enhancer being sufficient to cause the benzodiazepine to pass through the skin at a rate in excess of about one µg/cm2/hr. A release lamina (13) is also provided.

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