Transdermal administration of tamsulosin

Details Transdermal administration of tamsulosin Transdermal administration of tamsulosin

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/137 (2006.01) A61K 31/18 (2006.01) A61K 47/06 (2006.01)

Patent

CA 2751884

In an aspect of the inven-tion, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt% tamsulosin or a phar-maceutically acceptable salt of tamsu-losin, (b) at least about 40 wt% poly-isobutylene adhesive or hydrophobic syn-thetic rubber adhesive, (c) about 1 -20 wt % of an aprotic solvent in which tamsu-losin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha--hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hy-droxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.

Dans un aspect, la présente invention concerne une composition pour la fabrication d'un timbre transdermique destiné à la délivrance transdermique de tamsulosine. La composition comprend (a) au moins environ 1 % en poids de tamsulosine ou d'un sel pharmaceutiquement acceptable de tamsulosine, (b) au moins environ 40 % en poids d'un adhésif à base de polyisobutylène ou d'un adhésif à base de caoutchouc synthétique et hydrophobe, (c) environ 1 à 20 % en poids d'un solvant aprotique dans lequel la tamsulosine se dissout rapidement, (d) environ 1 à 20 % en poids d'un acide gras insaturé ou d'un alpha-hydroxy acide, ou d'un mélange d'acides gras insaturés ou d'alpha-hydroxy acides, ou un mélange d'acides gras insaturés et d'alpha-hydroxy acides, (e) un améliorateur de perméation lipophile, et (f) un modificateur de matrice.

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