Transdermal carrier materials

Details Transdermal carrier materials Transdermal carrier materials

C - Chemistry, Metallurgy

07

D

167/300, 260/461

C07D 233/26 (2006.01) A61K 9/70 (2006.01) A61K 31/415 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) C07D 233/14 (2006.01) C07D 233/16 (2006.01)

Patent

CA 1154024

ABSTRACT OF THE DISCLOSURE Amphoteric dissociating complexes which have a cationic group having the structure Image or Image wherein: R1 is an aliphatic alkyl group having 6 to 22 carbons, R2 is a member of the group consisting of -R4-(CH2 CH2)-COOH, -R4-(CH=CH)COOH and -OPO3H2, wherein R4 is -NH-, - NH-CO-, or -O-CO-, and R3 is hydrogen, -CH2-COOH or -CH2-CH2-COOH; and an anionic group which is either a carboxylate having the formula -OOC-CH2-(O-CH2-CH2)x-OCnH2n + 1 or a phosphate having the formula =O3PO-CH2-CH2-(OCH2-CH2)x-OCnH2n + 1 wherein: n is 8 to 22 and x is 1 to 10; and z is 1 when the anionic radical is a carboxylate and z is 2 when the anionic radical is a phosphate are disclosed. The compositions are effective carriers for active pharmaceutical or cosmetic ingredients. The active ingredients may be ionically complexed with the cationic or anionic group of the amphoteric complex or may be covalently bonded to one of the groups of the complex. Alternatively, the active substances may be transported in the carriers as micellar inclusions.

375367

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