Transdermal composition

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 9/06 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2065134

A B S T R A C T The invention concerns an anhydrous transdermal preparation comprising in a 20-100 % lyotropic liquid crystalline arrange- ment 5-15 w.% of optically active or racemic N-methyl-N- -(phenyl-2-propyl)-2-propinylamine or N-methyl-(1-(4-fluoro-phenyl)-2-propyl)-2- -propylamine or their therapeutically sui- table salts, 40-70 w.% of liquid polyoxiethylene, 10-20 w % of solid polyoxiethylene, 2-30 w.% of a nonionic surface active agent, 2-20 w.% of propyleneglycol, if desired 0.5-2 w.% of a polymer the a value of which is > 0.6, and if desired in a quantity needed to 100 w.%, other auxili- ary agents.

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