Transdermal delivery of hydrophobic bioactive agents

Details Transdermal delivery of hydrophobic bioactive agents Transdermal delivery of hydrophobic bioactive agents

A - Human Necessities

61

K

A61K 6/00 (2006.01)

Patent

CA 2579642

A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT3) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

Selon la présente invention, une méthode et une composition associée, y compris l'utilisation de dérivés de N-acyle de sarcosine, permettent d'administrer des agents bioactifs à travers des surfaces tissulaires, telles que la peau. Cette méthode et cette composition sont, particulièrement, appropriées à des agents actifs hydrophobes, tels que des antagonistes du récepteur de la sérotonine (5HT3) (par ex., ondasétron), des agents antipsychotiques (par ex., rispéridone), des benzodiazépines (par ex., flumazénil) et des progestines (par ex., lévonorgestrel).

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