A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2489865
A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.
La présente invention concerne une composition pharmaceutique destinée à un apport transdermique, qui comprend un ou plusieurs agents physiologiquement actifs, un ou plusieurs activateurs de pénétration dermique et un excipient volatil répondant aux normes pharmaceutiques comprenant un solvant volatil. L'agent physiologiquement actif et l'activateur de pénétration dermique forment un dépôt amorphe lors de l'évaporation de l'excipient volatil, ce dépôt amorphe formant un réservoir à l'intérieur de la couche cornée. (A) Cette composition possède un profil de vitesse de libération de l'agent physiologiquement actif de façon à offrir un rapport de concentration maximum (C¿max?) sur la concentration moyenne (C¿avg?) de l'agent physiologiquement actif sur un intervalle de dose compris entre 1 à 10.
Finnin Barrie Charles
Klose Kathryn Traci-Jane
Morgan Timothy Matthias
Reed Barry Leonard
Wilkins Nina Frances
Acrux Dds Pty Ltd
Blake Cassels & Graydon Llp
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