A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/159
A61K 47/00 (2006.01) A61K 9/70 (2006.01) A61K 31/21 (2006.01) A61K 31/565 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)
Patent
CA 1280974
ABSTRACT OF THE DISCLOSURE Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol and/or oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
524665
Bodor Nicholas
Loftsson Thorsteinn
Bodor Nicholas
Key Pharmaceuticals Inc.
Loftsson Thorsteinn
Swabey Ogilvy Renault
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