Transdermal delivery system for delivering nitroglycerin at...

A - Human Necessities – 61 – M

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167/159, 167/251

A61M 37/00 (2006.01) A61K 9/70 (2006.01) A61K 31/21 (2006.01)

Patent

CA 1262098

ABSTRACT OF THE DISCLOSURE A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 ug/cm2hr and preferably in the range of 50- 150 ug/cm2hr. Ethanol delivered at a rate of from 250-500 ug/cm2hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 1170 and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure. 14

508211

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