A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
167/159, 167/251
A61M 37/00 (2006.01) A61K 9/70 (2006.01) A61K 31/21 (2006.01)
Patent
CA 1262098
ABSTRACT OF THE DISCLOSURE A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 ug/cm2hr and preferably in the range of 50- 150 ug/cm2hr. Ethanol delivered at a rate of from 250-500 ug/cm2hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 1170 and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure. 14
508211
Berggren Randall G.
Gale Robert M.
Alza Corporation
Berggren Randall G.
Gale Robert M.
Smart & Biggar
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