Transdermal delivery system for use with basic permeation...

Details Transdermal delivery system for use with basic permeation... Transdermal delivery system for use with basic permeation...

A - Human Necessities

61

F

A61F 13/00 (2006.01)

Patent

CA 2564341

The present invention includes transdermal delivery systems having a polymeric active agent reservoir fabricated from an admixture of polyisobutylene and an insoluble hydrophilic polymer in powdered form, which provide numerous advantages in the transdermal delivery of active agents using basic enhancer compositions. For example, the systems of the invention provide for (1) increased permeation of the active agent through the skin, (2) an improved capability of extracting the active agent and enhancer from the transdermal systems, (3) enhanced structural integrity, (4) good chemical stability, (5) reduced phase separation, and (6) decreased cold flow.

La présente invention a trait à des systèmes d'administration transdermiques comportant un réservoir d'agents polymériques actifs produits à partir d'un mélange de polyisobutylène et d'un polymère hydrophile insoluble sous forme de poudre, assurant de nombreux avantages dans l'administration transdermique d'agents actifs au moyen de compositions basiques renforçantes. Par exemple, les systèmes de l'invention assurent (1) une pénétration accrue de l'agent actif à travers la peau, (2) une capacité améliorée d'extraction de l'agent actif et l'agent d'activation des systèmes transdermiques, (3) une intégrité structurelle renforcée, (4) une bonne stabilité chimique, (5) une séparation de phase réduite, et (6) un fluage à froid réduit.

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