Transdermal delivery system of hormones without penetration...

Details Transdermal delivery system of hormones without penetration... Transdermal delivery system of hormones without penetration...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2549916

The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.

La présente invention se rapporte à un timbre comportant une couche renfermant un médicament à faible teneur en hormones, par exemple un gestodène, et éventuellement un oestrogène (par exemple éthinyloestradiol). Lorsqu'une femme reçoit ce timbre, son taux de gestodène plasmatique est porté à 1,0 ng/ml dans des conditions constantes, l'adjonction à la couche renfermant le médicament d'agents facilitant la pénétration ou la perméation étant superflue. Des taux plasmatiques satisfaisants des hormones sont également obtenus pendant au moins une semaine, ce timbre étant ainsi utilisable à des fins de contraception chez la femme sur la base d'une fréquence d'administration hebdomadaire du timbre.

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