Transdermal device comprising non-steroidal...

Details Transdermal device comprising non-steroidal... Transdermal device comprising non-steroidal...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/196 (2006.01) A61K 31/405 (2006.01) A61K 31/5415 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2366852

This invention pertains to transdermal administration devices, and more particularly, to transdermal administration devices that contain: (a) a pharmaceutical composition for the systemic administration of a NSAID; (b) a backing layer; and, (c) a release liner; wherein said pharmaceutical composition includes at least one component that enhances percutaneous permeation selected from: (i) fatty alcohols (C4-C30); (ii) mono, di or triglyceryl fatty acid esters (C4-C30); and, (iii) fatty acid esters (C4-C30); and a pressure sensitive acrylic adhesive matrix formed by a copolymer with polar functional groups in which the NSAID is incorporated.

L'invention concerne des dispositifs d'administration par voie transdermique, et plus particulièrement, des dispositifs d'administration par voie transdermique qui contiennent: (a) une composition pharmaceutique pour l'administration systémique d'un anti-inflammatoire non stéroïdien; (b) une couche de renforcement; et (c) une garniture détachable. Ladite composition pharmaceutique comprend au moins un composant améliorant la pénétration percutanée choisi dans le groupe constitué: (i) d'alcools gras (C¿4?-C¿30?); (ii) d'esters d'acides gras mono-, di- ou triglycéryles (C¿4?-C¿30?); et (iii) d'esters d'acides gras (C¿4?-C¿30?). Ladite composition pharmaceutique comprend également une matrice adhésive acrylique sensible à la pression constituée d'un copolymère avec des groupes fonctionnels polaires, dans laquelle est intégré l'anti-inflammatoire non stéroïdien.

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