Transdermal drug delivery device comprising extensor-relaxor...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01)

Patent

CA 2618033

A transdermal drug delivery device comprises a reservoir layer (10), which consists of one or more chambers (24) for containing a drug. A lower surface of the reservoir layer (10) is bounded by a resilient membrane (12), which is perforated by pores (26) through which the drug may be delivered from the chambers (24). Connected to the reservoir layer (10) is an extensor means (18), which can be actuated by control means (22) to deform the reservoir layer (10) such that the chambers (24) are compressed and the pores (26) are enlarged, thereby forcing the drug from the chambers (24) through the pores (26) and into contact with the patient~s skin (30). When the resilient membrane (12) is adhered to the skin (30), the extension and relaxation of the device causes simultaneous stretching and relaxation of the skin (30), disrupting the barrier presented by the skin~s surface and enhancing delivery of the drug.

Un dispositif de relargage de médicament par voie transdermique comprend une couche réservoir (10) qui consiste en au moins deux chambres (24) destinées à contenir un médicament. Une surface inférieure de la couche réservoir (10) est délimitée par une membrane élastique (12) perforée de pores par lesquels le médicament peut être largué des chambres (24). Un moyen extenseur (18), relié à la couche réservoir (10), peut être actionné par un moyen de commande (22) pour déformer la couche réservoir (10), de sorte que les chambres (24) soient comprimées, que les pores (26) soient agrandis, afin que le médicament se trouvant dans les chambres soit mis en contact avec la peau du patient (30) en passant par les pores. Lorsque la membrane élastique (12) est collée à la peau (30), l'extension et la relaxation du dispositif induisent l'étirement et la relaxation simultanées de la peau (30), ce qui rompt la barrière formée par la surface de la peau et favorise le relargage du médicament.

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