Transdermal drug delivery devices having coated...

Details Transdermal drug delivery devices having coated... Transdermal drug delivery devices having coated...

A - Human Necessities

61

M

A61M 37/00 (2006.01) A61K 9/70 (2006.01) A61M 35/00 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2427381

A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

L'invention concerne un dispositif (12) et un procédé destinés à l'administration transdermique percutanée d'un principe actif pharmacologiquement puissant. Le principe actif est dissous dans de l'eau afin de former une solution d'enrobage liquide présentant une viscosité appropriée pour recouvrir de minuscules éléments perçant la peau (10). La solution d'enrobage est appliquée sur les éléments perçant la peau (10)par le biais de techniques d'enrobage connues, puis il est séché. Le dispositif (12) est appliqué sur la peau d'un être vivant (un être humain, par exemple), entraînant les microprotrusions (10) à percer la couche cornée de l'épiderme, et administre une dose de principe actif à effet thérapeutique au sujet.

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