A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
167/159
A61M 37/00 (2006.01) A61K 9/70 (2006.01)
Patent
CA 1253074
TRANSDERMAL DRUG DELIVERY DEVICES WITH AMINE-RESISTANT SILICONE ADHESIVES Abstract This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure- sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R3SiO1/2 units and SiO4/2 units and a polydiorganosiloxane which have been chemically treated with R3SiO1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.
493704
Metevia Virgil L.
Woodard John T.
Dow Corning Corporation
Gowling Lafleur Henderson Llp
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