Transdermal drug delivery process

Details Transdermal drug delivery process Transdermal drug delivery process

A - Human Necessities

61

N

A61N 1/30 (2006.01) A61K 38/23 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2171910

A calcitonin, its derivative or a salt thereof is transdermally delivered by iontophoresis in which a sub- stantially constant voltage in the range of 3 to 20 V is applied at an electric current of 0.05 to 0.5 mA/cm2. In this process, the calcitonin can be delivered trans- dermally with a higher absorptivity by applying a higher voltage for a short period (at a voltage of about 6 to 14 V for about 5 to 15 minutes) in the initial stage of the voltage application, and then applying a lower volt- age for a long period (at a voltage of about 3 to 9 V for about 30 to 40 minutes).

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