A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/05 (2006.01) A61K 31/196 (2006.01) A61K 45/06 (2006.01) A61K 47/02 (2006.01) A61K 47/32 (2006.01)
Patent
CA 2427764
The present invention relates to an adhesive based transdermal drug delivery system, having excellent water absorbability, comprising a backing film, an adhesive matrix containing active ingredients and a release liner which is peelable prior to use. The matrix layer of the present invention is a multilayered sandwich and comprises drug containing outer adhesive layers, adhering to the backing film and release liner respectively, between which is sandwiched an absorption enhancer layer. The adhesive layers comprise (a) an acrylate adhesive, (b) a mixture of high and low molecular weight polyvinylpyrrolidones, and (c) a colloidal silica.
La présente invention concerne un système d'administration de médicaments transdermique à base adhésive, présentant une très bonne absorption de l'eau. Ledit système est composé d'une pellicule de doublure, d'une matrice adhésive contenant des agents actifs, et d'un revêtement amovible pouvant être retiré avant utilisation. La couche matrice selon l'invention est de type sandwich multicouche et comporte des couches adhésives extérieures contenant des médicaments, adhérant respectivement à la pellicule de doublure et au revêtement amovible, une couche d'amplificateur d'absorption étant logée en sandwich entre lesdites couches adhésives. Ces couches adhésives contiennent (a) un adhésif acrylate ; (b) un mélange de polyvinylpyrrolidones de masses moléculaires faibles et élevées ; et, (c) une silice colloïdale.
Kim Dong Won
Song Jin Deog
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Samyang Corporation
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