Transdermal drug delivery using an osmolyte and vasoactive...

Details Transdermal drug delivery using an osmolyte and vasoactive... Transdermal drug delivery using an osmolyte and vasoactive...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2702604

A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

L'invention concerne une formulation et un procédé d'administration de substances bioactives à appliquer sur ou dans la peau ou une autre région externe d'un mammifère, par exemple, un patient, la formulation comprenant un agent vasoactif, un osmolyte et un ingrédient actif. La formulation est suffisamment hygroscopique pour créer un état d'hypertonicité lorsqu'elle est absorbée par la peau. Lorsque la formulation est appliquée sur la peau, l'agent vasoactif peut être délivré au derme de façon à entrer en contact avec le système vasculaire du patient.

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